Business Hotels in San Diego

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
17 Jul - 19 Jul
Next weekend
24 Jul - 26 Jul

Business Hotels in San Diego

Studio Suite, 1 King Bed with Sofa bed, Balcony | View from room

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
Harbor Island
8.4 out of 10, Very good, (3,577 reviews)
The price is £181
includes taxes & fees
16 Aug - 17 Aug
Sheraton San Diego Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See more propertiesforward arrow

Top neighbourhoods in San Diego

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Step into San Diego's Gaslamp Quarter where Victorian-era streetlights cast a warm glow over cobblestone paths lined with historic buildings. This walkable entertainment district buzzes with rooftop bars, live music venues, and bustling nightlife. History buffs will appreciate the beautifully restored 1880s architecture and landmarks like the Gaslamp Museum at the Davis-Horton House. Dining options range from upscale steakhouses to craft breweries serving late into the night. Most attractions are within easy walking distance, especially during evenings when many streets become pedestrian-only zones. The nearby trolley stops connect visitors to broader San Diego attractions when you're ready to explore beyond this lively historic area.

A beach with surfers and swimmers during sunset.

Pacific Beach

Pacific Beach blends laid-back surf culture with direct entertainment along San Diego's stunning coastline. The buzzing boardwalk invites biking, skating, or people-watching as waves crash nearby. Crystal Pier stretches into the ocean, offering perfect sunset views, while Mission Bay provides calm waters for paddleboarding and kayaking. Casual beachfront eateries serve everything from fish tacos to acai bowls, with most spots offering ocean-view patios. Accommodation range from budget motels to luxury oceanfront rentals, all within walking distance of the sand. While public transit is limited, the neighborhood's walkable design and extensive bike paths make exploring this sun-soaked playground a breeze.

A white church with a cross on top and a curved roof against a clear blue sky.

Mission Valley

Mission Valley puts you right in San Diego's action-packed middle with everything a traveller needs. Two major malls (Fashion Valley and Mission Valley Centre) offer retail therapy while Riverwalk Golf Club provides a scenic escape. The San Diego River creates a natural backdrop as trolley bells chime at nearby stations, making it easy to explore beyond the area. Getting around couldn't be simpler with three trolley stations and multiple motorways connecting you to San Diego's attractions. Hotels line the valley at various price points, creating a convenient base for day trips to nearby beaches, Old Town, or the famous San Diego Zoo.

A street with a 'Little Italy' sign, parked cars, and buildings with Italian flags.

Little Italy

San Diego's arty Little Italy neighbourhood is loved for its restaurants and port, and visitors often enjoy its varied attractions, including Maritime Museum of San Diego and San Diego Bay.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

San Diego's Mission Beach neighbourhood has lots of places to visit, such as Mission Beach and Mission Bay.

Top landmarks in San Diego

A zoo entrance with a panda sculpture, ticket booth, and people.

San Diego Zoo

9.2/10 (15,439 reviews)
It's feeding time at the zoo! If you can't resist those cuddly critters, you might want to pay a visit to San Diego Zoo, located 1.5 mi (2.4 km) from central San Diego. Hotels.com travellers also say the area is artistic and that it has lots of nice beaches. If you have fun at San Diego Zoo, you'll love San Diego Natural History Museum and Spanish Village Art Center, both a short walk away.
See properties

Frequently asked questions

What are the best business hotels in San Diego?
Based on guest reviews, Pendry San Diego is one of the best business hotels in San Diego. Make the most of a conference space and a poolside bar here. Tower23 Hotel is also designed with corporate travellers in mind. It's another visitor favourite.
What are the cheapest business hotels in San Diego?
Crown City Inn is a budget-friendly option catering to professionals. This property offers a 24-hour front desk and a 24-hour business centre. Also consider  Hampton Inn & Suites San Diego Airport Liberty Station. Take your pick of affordable San Diego business hotels from £85 that are a win for both your wallet and your work.
What is the best time to stay in a business hotel in San Diego?
If you're looking for the warmest weather, organise your work trip for August. The temperatures are around 20ºC to 26ºC during this time. December sees the coolest temperatures between 12ºC and 18ºC. For smaller crowds and potentially cheaper business hotels in San Diego, visit in January when it's quieter.
What are the closest business hotels to San Diego Zoo?
TownePlace Suites by Marriott San Diego Downtown will put you close to San Diego Zoo. This business-friendly stay comes with a terrace and laundry services. Alternatively, base yourself at Abpopa Hillcrest. It's also a quick drive from this attraction. Find your perfect business hotel in San Diego and let the adventures begin once your work is done.
What business hotels in San Diego have a pool?
Work hard and relax harder at Pendry San Diego. This sought-after San Diego business hotel with a pool offers access to a cafe and an electric car charging station. Or, clear out those emails while lounging by the water at Crown City Inn.
What are the closest business hotels to San Diego Intl. Airport (SAN)?
Hop off the plane and into your next meeting at Sheraton San Diego Resort. This top business stay is about 2 km (1 mile) south of San Diego Intl. Airport (SAN). You can make use of a garden, an electric car charging station and more here. Courtyard by Marriott San Diego Airport/Liberty Station is another great choice. Explore the full range of business hotels in San Diego and other locations that were made for jet-setting professionals.
What are the best 5-star business hotels in San Diego?
Offering a cafe and a swimming pool, Pendry San Diego was designed for executives who expect nothing but the best. Another 5-star San Diego business hotel that promises to upgrade your work trip is The US Grant, a Luxury Collection Hotel, San Diego.
Are there any business hotels in San Diego with parking?
Make business trips smoother by staying at Pendry San Diego. This getaway comes with parking, a poolside bar and a bar. Tower23 Hotel is another stay that includes a spot for your wheels. If you're looking for alternatives, check out the 7,058 San Diego business hotels with parking.

Keep exploring