Hotels in Defiance

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Best Defiance Hotels

Hotels.com currently has 10 hotels in Defiance!

Our 5 most booked Defiance hotels from the last hour are:

1. Sleep Inn and Suites
2. Residence Inn by Marriott O'Fallon
3. Staybridge Suites O'Fallon Chesterfield
4. Wingate by Wyndham St. Charles MO
5. Hilton Garden Inn St. Louis/O'Fallon


But, low prices and a great selection are not the only thing Hotels.com offers. We also have 0 genuine Hotels.com guest reviews for Defiance.

Why use Hotels.com to book your Defiance accommodation?

We can help you to find the perfect Defiance hotel room for almost any occasion. With our fast and secure hotel search you may compare different Defiance hotels by:

  • - Price
  • - Availability
  • - Defiance neighbourhoods
  • - Nearby Defiance attractions and landmarks
  • - 0 genuine Hotels.com guest reviews for Defiance
  • - Star rating
  • - Amenities
  • - Hotel name & chain
  • - Theme


Alternatively, you can use our detailed Defiance maps showing hotel locations in Defiance, using all the filters listed above.

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