Hotels in Seneca

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Check prices for these dates

Tonight
28 Aug - 29 Aug
Tomorrow
29 Aug - 30 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Top 5 hotels in Seneca at a glance

  1. Best Western Seneca-Clemson — 2.5-star hotel in Seneca. Guest rating: 8.4/10 — Very good.
  2. Quality Inn Seneca US-123 — 2.5-star hotel in Seneca. Guest rating: 8.0/10 — Very good.
  3. Tru by Hilton Seneca Clemson — 2.5-star hotel in Seneca. Guest rating: 9.2/10 — Wonderful.
  4. Fairfield Inn & Suites Seneca Clemson Univ Area — 3-star hotel in Seneca. Guest rating: 9.4/10 — Exceptional.
  5. Lakeside Lodge Clemson — 2.5-star hotel in Seneca. Guest rating: 9.0/10 — Wonderful.

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on comfort, location and traveller experience. Last updated on .

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
£78
includes taxes & fees
30 Aug - 31 Aug
Best Western Seneca-Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
£66
includes taxes & fees
3 Sept - 4 Sept
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
£86
includes taxes & fees
6 Sept - 7 Sept
Tru by Hilton Seneca Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
£97
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
£100
includes taxes & fees
29 Aug - 30 Aug
Lakeside Lodge Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
£99
includes taxes & fees
27 Sept - 28 Sept
Hampton Inn & Suites Seneca-Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
£107
includes taxes & fees
1 Sept - 2 Sept
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
£66
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
£86
includes taxes & fees
6 Sept - 7 Sept
Hampton Inn Clemson-University Area

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
£122
includes taxes & fees
1 Sept - 2 Sept
Clemson University's James F. Martin Inn

Inn @ Clemson

Inn @ Clemson
Clemson
£63
includes taxes & fees
1 Sept - 2 Sept
Inn @ Clemson

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
£83
includes taxes & fees
30 Aug - 31 Aug
Best Western Plus Clemson Hotel & Conference Center

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
£86
includes taxes & fees
20 Sept - 21 Sept
Comfort Inn & Suites Clemson - University Area

Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
£63
includes taxes & fees
26 Sept - 27 Sept
Rodeway Inn & Suites Walhalla

The Abernathy of Clemson

The Abernathy of Clemson
Clemson
£124
includes taxes & fees
2 Sept - 3 Sept
The Abernathy of Clemson

Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
£96
includes taxes & fees
3 Sept - 4 Sept
Courtyard Marriott Clemson

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
£90
includes taxes & fees
31 Aug - 1 Sept
Holiday Inn Express & Suites Clemson by IHG

Clemson Memorabilia House

Clemson Memorabilia House
Clemson
£175
includes taxes & fees
30 Aug - 31 Aug
Clemson Memorabilia House

The Inn at Patrick Square

The Inn at Patrick Square
Clemson
£122
includes taxes & fees
30 Aug - 31 Aug
The Inn at Patrick Square

Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
Clemson
£65
includes taxes & fees
29 Aug - 30 Aug
Days Inn by Wyndham Clemson
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Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
£77
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
£92
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
£65
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
£112
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
£100
for 1 room
includes taxes & fees
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
£121
for 1 room
includes taxes & fees
Tru by Hilton Seneca Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
£121
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
£169
for 1 cabin
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
£77
for 1 room
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
£92
for 1 room
includes taxes & fees
Best Western Seneca-Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
£112
for 1 room
includes taxes & fees
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
£112
for 1 room
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
£100
for 1 room
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
£67
for 1 room
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
£121
for 1 room
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
£177
for 1 cabin
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
£184
for 2 nights, 1 room
£92 per night
includes taxes & fees
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
£146
for 2 nights, 1 room
£73 per night
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
£177
for 2 nights, 1 room
£89 per night
includes taxes & fees
Best Western Seneca-Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
£209
for 2 nights, 1 room
£105 per night
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
£241
for 2 nights, 1 room
£121 per night
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
£216
for 2 nights, 1 room
£108 per night
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
£148
for 2 nights, 1 room
£74 per night
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
£52 off
£359
for 2 nights, 1 cabin
£180 per night
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
£518
for 2 nights, 1 cottage
£259 per night
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
£614
for 2 nights, 1 apartment
£307 per night
includes taxes & fees
Screened Patio & Yard: Clemson Weekends/lakes Stay

Condo on Lake Hartwell 3 Mi to Clemson Stadium

Condo on Lake Hartwell 3 Mi to Clemson Stadium
Seneca
£535
for 2 nights, 1 apartment
£267 per night
includes taxes & fees
Condo on Lake Hartwell 3 Mi to Clemson Stadium

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
£1,207
for 2 nights, 1 apartment
£603 per night
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
Seneca
£788
for 2 nights, 1 apartment
£394 per night
includes taxes & fees
Lakefront Seneca Vacation Rental w/ Shared Dock!

Check out pet-friendly hotels in Seneca

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
£86
includes taxes & fees
6 Sept - 7 Sept
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
£66
includes taxes & fees
3 Sept - 4 Sept
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
£100
includes taxes & fees
29 Aug - 30 Aug
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
£66
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
£107
includes taxes & fees
1 Sept - 2 Sept
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
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You may also like hotels with pools in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
£100
includes taxes & fees
29 Aug - 30 Aug
Lakeside Lodge Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
£78
includes taxes & fees
30 Aug - 31 Aug
Best Western Seneca-Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
£66
includes taxes & fees
3 Sept - 4 Sept
Quality Inn Seneca US-123

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
£99
includes taxes & fees
27 Sept - 28 Sept
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
£97
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
£66
includes taxes & fees
30 Aug - 31 Aug
Days Inn by Wyndham Seneca / Clemson Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in August
Typical weather for Seneca
August
High 31°C / low 20°C. Sunny most days.
View properties in August
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12°
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12°
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10°
26°
15°
31°
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Monthly weather averages (˚C)

Top neighbourhoods in Seneca

Downtown

City centre Seneca charms visitors with well-preserved historical buildings that tell the storey of its railway heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodation range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire city centre is walkable with wide pavements, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Holiday rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront holiday homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in holiday rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Seneca City Hall

Seneca City Hall is worth a pic or two when discovering Downtown.
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Highpointe Lower Field

Highpointe Lower Field is worth a visit, located 5.7 mi (9.1 km) from central Seneca.
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The Gauntlet

If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

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A calm lake with mountains in the background.

Check out reviews of Seneca hotels guests love

Quality Inn Seneca US-123

Quality Inn Seneca US-123

10/10 Excellent
"Convenient location. Reasonably priced. Staff is very friendly and helpful."
Kwanchanok 1-night trip
Posted 15 hours ago
Quality Inn Seneca US-123

Frequently asked questions

How much does a hotel room cost in Seneca?
You can find top hotels in Seneca from £54 with options to suit your budget and needs. If you're after an affordable hotel in Seneca that meets all of your requirements, set your filters and then sort the results by "Price: low to high".
How much does a hotel room cost in Seneca?
You can find top hotels in Seneca from £54 with options to suit your budget and needs. If you're after an affordable hotel in Seneca that meets all of your requirements, set your filters and then sort the results by "Price: low to high". If you're a member, don't forget to sign in to your account to unlock more savings.
How can I find deals and earn rewards at Seneca hotels?
Discover great deals on Seneca hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. And make sure to check out our last-minute deals on Seneca hotels.
How can I find deals and earn rewards at Seneca hotels?
Members can save up to 20% on select hotels in Seneca. Plus, Silver, Gold and Platinum members earn extra rewards on VIP Access bookings, making each stay even more rewarding.
Can I book Seneca hotels with free cancellation?
In order to book a refundable Seneca hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some of the best Seneca hotels with free parking?
If you're exploring by car, finding a great Seneca hotel with free parking is a win. Our travellers' favourites include:
What hotels do travellers recommend in Seneca?
Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 218 holiday homes. In addition, there are 21 apartments and 12 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

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