Photo by Bill Dillard
Hotels in Southeast Missouri
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15 Nov - 16 NovTomorrow
16 Nov - 17 NovNext weekend
21 Nov - 23 NovIn two weeks
28 Nov - 30 NovWhere to stay in Southeast Missouri?




Drury Inn & Suites Sikeston, MO
£84
includes taxes & fees
20 Nov - 21 Nov




La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
£69
includes taxes & fees
16 Nov - 17 Nov




Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
£78
includes taxes & fees
30 Nov - 1 Dec




Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
£51
includes taxes & fees
16 Nov - 17 Nov




Super 8 by Wyndham Charleston/Sikeston East MO
£47
includes taxes & fees
16 Nov - 17 Nov




Pear Tree Inn Cape Girardeau West
£60
includes taxes & fees
20 Nov - 21 Nov




Fairfield Inn & Suites by Marriott Poplar Bluff
£89
includes taxes & fees
7 Dec - 8 Dec




Shepherd Mountain Inn




Honeysuckle Inn - Mountain View
£79
includes taxes & fees
16 Nov - 17 Nov




Drury Plaza Hotel Cape Girardeau Conference Center
£77
includes taxes & fees
1 Dec - 2 Dec




New Orleans Inn Portageville




Holiday Inn Express & Suites Sikeston Southwest by IHG
£87
includes taxes & fees
23 Nov - 24 Nov




EC Reed's Mercantile and Hotel




Drury Inn & Suites Poplar Bluff
£81
includes taxes & fees
23 Nov - 24 Nov
Great weekend hotel deals in Southeast Missouri, MO
Showing deals for:28 Nov - 30 Nov

Tiny Houses of French Village
French Village
10/10Exceptional (3 reviews)
£444
for 2 nights, 1 home
£222 per night
includes taxes & fees

Tru By Hilton Cape Girardeau
Cape Girardeau
9.6/10Exceptional (91 reviews)
£178
for 2 nights, 1 room
£89 per night
includes taxes & fees

Hampton Inn Farmington
Farmington
8.8/10Excellent (514 reviews)
£227
for 2 nights, 1 room
£113 per night
includes taxes & fees

Honeysuckle Inn - Mountain View
Mountain View
8.6/10Excellent (327 reviews)
£169
for 2 nights, 1 room
£85 per night
includes taxes & fees

The Riverview
Cape Girardeau
9.4/10Exceptional (452 reviews)
£257
for 2 nights, 1 room
£129 per night
includes taxes & fees

Arcadia Academy
Arcadia
9.8/10Exceptional (11 reviews)
£182
for 2 nights, 1 room
£91 per night
includes taxes & fees

Century Casino & Hotel Caruthersville
Caruthersville
8.4/10Very good (91 reviews)
£210
for 2 nights, 1 room
£105 per night
includes taxes & fees

Crown Pointe Lodge, BW Signature Collection
Farmington
9.0/10Wonderful (564 reviews)
£180
for 2 nights, 1 room
£90 per night
includes taxes & fees

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
9.6/10Exceptional (770 reviews)
£170
for 2 nights, 1 room
£85 per night
includes taxes & fees

EC Reed's Mercantile and Hotel
Marble Hill
9.6/10Exceptional (82 reviews)
£191
for 2 nights, 1 room
£96 per night
includes taxes & fees

Current River Inn
Van Buren
8.2/10Very good (162 reviews)
£151
for 2 nights, 1 room
£75 per night
includes taxes & fees

The Farmstead Hotel
Caruthersville
8.8/10Excellent (445 reviews)
£148
for 2 nights, 1 room
£74 per night
includes taxes & fees

Rockwood Inn
Cape Girardeau
10/10Exceptional (17 reviews)
£309
for 2 nights, 1 room
£154 per night
includes taxes & fees

Best Western Plus Sikeston
Sikeston
8.4/10Very good (1,003 reviews)
£149
for 2 nights, 1 room
£74 per night
includes taxes & fees

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
8.8/10Excellent (650 reviews)
£130
for 2 nights, 1 room
£65 per night
includes taxes & fees

Shepherd Mountain Inn
Ironton
9.4/10Exceptional (303 reviews)
£204
for 2 nights, 1 room
£102 per night
includes taxes & fees

New Orleans Inn Portageville
Portageville
8.0/10Very good (721 reviews)
£108
for 2 nights, 1 room
£54 per night
includes taxes & fees
Check out pet-friendly hotels in Southeast Missouri




Drury Inn & Suites Sikeston, MO
Sikeston
£84
includes taxes & fees
20 Nov - 21 Nov




Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
£77
includes taxes & fees
1 Dec - 2 Dec




Pear Tree Inn Cape Girardeau West
Cape Girardeau
£60
includes taxes & fees
20 Nov - 21 Nov




Holiday Inn Poplar Bluff by IHG
Poplar Bluff
£87
includes taxes & fees
23 Nov - 24 Nov




Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
£51
includes taxes & fees
16 Nov - 17 Nov




Hampton Inn Poplar Bluff
Poplar Bluff
£80
includes taxes & fees
23 Nov - 24 Nov




Drury Inn & Suites Poplar Bluff
Poplar Bluff
£81
includes taxes & fees
23 Nov - 24 Nov




Bullwinkles Rustic Lodge
Poplar Bluff
You may also like hotels with hot tubs in Southeast Missouri




Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
£77
includes taxes & fees
1 Dec - 2 Dec




Drury Inn & Suites Jackson MO
Jackson
£71
includes taxes & fees
16 Nov - 17 Nov




Drury Inn & Suites Poplar Bluff
Poplar Bluff
£81
includes taxes & fees
23 Nov - 24 Nov




Crown Pointe Lodge, BW Signature Collection
Farmington
£86
includes taxes & fees
23 Nov - 24 Nov




New Orleans Inn Portageville
Portageville




Drury Inn & Suites Cape Girardeau
Cape Girardeau
£77
includes taxes & fees
23 Nov - 24 Nov




Quality Inn Perryville I-55
Perryville
£60
includes taxes & fees
26 Nov - 27 Nov




Drury Inn & Suites Hayti Caruthersville
Hayti
£81
includes taxes & fees
23 Nov - 24 Nov
You can also stay at hotels with a pool in Southeast Missouri




Best Western Plus Sikeston
Sikeston
£73
includes taxes & fees
23 Nov - 24 Nov




La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
£69
includes taxes & fees
16 Nov - 17 Nov




Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
£87
includes taxes & fees
23 Nov - 24 Nov




Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
£46
includes taxes & fees
30 Nov - 1 Dec




Super 8 by Wyndham Perryville
Perryville
£58
includes taxes & fees
25 Nov - 26 Nov




Drury Inn & Suites Sikeston, MO
Sikeston
£84
includes taxes & fees
20 Nov - 21 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all propertiesGo beyond your typical stay in Southeast Missouri
Pet friendly
Family friendly
Cottage
Top landmarks in Central United States

Southeast Missouri State University
4.4/5 (137 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
Photo by Pat Long
Elephant Rocks State Park
4.8/5 (52 reviews)
Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay?
Photo by JG Morris
Lake Wappapello
4.3/5 (40 reviews)
Lake Wappapello is 1.8 mi (2.9 km) from central Wappapello, why not stop by during your stay?
Century Casino Caruthersville
3.2/5 (31 reviews)
Century Casino Caruthersville is 1 mi (1.6 km) from central Caruthersville, why not stop by during your stay?
Isle Casino Cape Girardeau
4.2/5 (104 reviews)
Isle Casino Cape Girardeau is 0.4 mi (0.7 km) from central Cape Girardeau, why not stop by during your stay?
Learn more about Southeast Missouri
Southeast Missouri, well known for its wineries and riverfront, features attractions such as Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants and sights like Lake Wappapello State Park and Clearwater Lake.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Check out reviews of Southeast Missouri hotels guests love
Fairfield Inn & Suites by Marriott Poplar Bluff
10/10 Excellent
"Everything was very good; checkin was simple and fast."
Tru By Hilton Cape Girardeau
10/10 Excellent
"Amaiah at the front desk was amazing! She Answered all my questions and double checked that our room was ready since I was a15 minutes early."
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
"Yes"
Courtyard by Marriott Cape Girardeau Downtown
10/10 Excellent
"The Room was very clean, We stayed on the 5th floor in a single king and the room had beautiful wood on the wall and boxed curtains. I really liked the layout. The staff was helpful, but we didn't need anything.
I will stay there again for sure.
I am not sure of the history of this building, but it was beautiful. It looked like old office building or something and the halls still looked like that. They had excellent midcentury styling. Even a letter shoot in the hall way, you can't use that though. The lobby was beautiful and if you need a cup of coffee there are two shops within throwing distance and I believe the lobby has Starbucks coffee in it.
"
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"The room was very clean. The front desk staff were courteous and helpful. "
The Riverview
10/10 Excellent
"Quiet clean room"
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Clean room and amenities were great"
Drury Inn & Suites Cape Girardeau
10/10 Excellent
"Clean and friendly staff!!!"
Pear Tree Inn Cape Girardeau Near the Medical Center
10/10 Excellent
"Nice place for a stay at a reasonable price."
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