Photo by Bill Dillard

Hotels in Southeast Missouri

Sat 22 Nov
Mon 24 Nov
November 2025
15
December 2025

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Check prices for these dates

Tonight
15 Nov - 16 Nov
Tomorrow
16 Nov - 17 Nov
Next weekend
21 Nov - 23 Nov
In two weeks
28 Nov - 30 Nov

Where to stay in Southeast Missouri?

£84
includes taxes & fees
20 Nov - 21 Nov
Drury Inn & Suites Sikeston, MO
£69
includes taxes & fees
16 Nov - 17 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
£74
includes taxes & fees
16 Nov - 17 Nov
The Farmstead Hotel
£61
includes taxes & fees
17 Nov - 18 Nov
Motel 6 Poplar Bluff, MO
£78
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
£51
includes taxes & fees
16 Nov - 17 Nov
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
£47
includes taxes & fees
16 Nov - 17 Nov
Super 8 by Wyndham Charleston/Sikeston East MO
£60
includes taxes & fees
20 Nov - 21 Nov
Pear Tree Inn Cape Girardeau West
£73
includes taxes & fees
23 Nov - 24 Nov
Best Western Plus Sikeston
£89
includes taxes & fees
7 Dec - 8 Dec
Fairfield Inn & Suites by Marriott Poplar Bluff
£71
includes taxes & fees
16 Nov - 17 Nov
Drury Inn & Suites Jackson MO
£82
includes taxes & fees
21 Nov - 22 Nov
Hampton Inn Sikeston
Shepherd Mountain Inn
£79
includes taxes & fees
16 Nov - 17 Nov
Honeysuckle Inn - Mountain View
£77
includes taxes & fees
1 Dec - 2 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
New Orleans Inn Portageville
£87
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express & Suites Sikeston Southwest by IHG
EC Reed's Mercantile and Hotel
£81
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Poplar Bluff
£56
includes taxes & fees
16 Nov - 17 Nov
Town House Inn
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Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:28 Nov - 30 Nov
House | Private kitchen | Fridge, oven, stovetop, toaster oven
House | Living area
House | 1 bedroom
House | Living area

Tiny Houses of French Village

French Village
10/10Exceptional (3 reviews)
9% off
£444
for 2 nights, 1 home
£222 per night
includes taxes & fees
Tiny Houses of French Village
Terrace/patio
Room, 2 Queen Beds
Indoor pool
Snack bar

Tru By Hilton Cape Girardeau

Cape Girardeau
9.6/10Exceptional (91 reviews)
20% off
£178
for 2 nights, 1 room
£89 per night
includes taxes & fees
Tru By Hilton Cape Girardeau
Lobby
Exterior
Premium bedding, pillow-top beds, in-room safe, laptop workspace
Lobby

Hampton Inn Farmington

Farmington
8.8/10Excellent (514 reviews)
20% off
£227
for 2 nights, 1 room
£113 per night
includes taxes & fees
Hampton Inn Farmington
Basic Single Room | Individually decorated, individually furnished, desk, blackout curtains
Children’s play area – outdoor
Free daily continental breakfast
Front of property

Honeysuckle Inn - Mountain View

Mountain View
8.6/10Excellent (327 reviews)
15% off
£169
for 2 nights, 1 room
£85 per night
includes taxes & fees
Honeysuckle Inn - Mountain View
Exterior
Lobby sitting area
Daily to-go breakfast for a fee
Grand Riverview Two Queen Room | 1 bedroom, premium bedding, pillow-top beds, in-room safe

The Riverview

Cape Girardeau
9.4/10Exceptional (452 reviews)
10% off
£257
for 2 nights, 1 room
£129 per night
includes taxes & fees
The Riverview
Deluxe Suite, Patio | Bathroom | Hair dryer, towels, soap, shampoo
Shared kitchen
Comfort Penthouse, Multiple Beds | Living area | TV
Room, Private Bathroom | 1 bedroom, free WiFi

Arcadia Academy

Arcadia
9.8/10Exceptional (11 reviews)
19% off
£182
for 2 nights, 1 room
£91 per night
includes taxes & fees
Arcadia Academy
View from property
Standard Double Room, 2 Queen Beds, Transfer Shower | Desk, laptop workspace, free WiFi
Interior
Shower, towels, soap, shampoo

Century Casino & Hotel Caruthersville

Caruthersville
8.4/10Very good (91 reviews)
10% off
£210
for 2 nights, 1 room
£105 per night
includes taxes & fees
Century Casino & Hotel Caruthersville
Free daily buffet breakfast
Lobby
Exterior
Standard Room, 1 King Bed, Jetted Tub, Golf View | Individually furnished, desk, blackout curtains, iron/ironing board

Crown Pointe Lodge, BW Signature Collection

Farmington
9.0/10Wonderful (564 reviews)
20% off
£180
for 2 nights, 1 room
£90 per night
includes taxes & fees
Crown Pointe Lodge, BW Signature Collection
Reception
Courtyard
Indoor pool
Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | In-room safe, desk, iron/ironing board, free cots/infant beds

Hampton Inn Cape Girardeau I 55 East

Cape Girardeau
9.6/10Exceptional (770 reviews)
20% off
£170
for 2 nights, 1 room
£85 per night
includes taxes & fees
Hampton Inn Cape Girardeau I 55 East
Exterior
Deluxe Double Room | Premium bedding, individually decorated, individually furnished
Lobby sitting area
Restaurant
VIP Access

EC Reed's Mercantile and Hotel

Marble Hill
9.6/10Exceptional (82 reviews)
10% off
£191
for 2 nights, 1 room
£96 per night
includes taxes & fees
EC Reed's Mercantile and Hotel
Deluxe Double Room | Individually decorated, individually furnished, blackout curtains
BBQ/picnic Area
Exterior
Children’s play area – outdoor

Current River Inn

Van Buren
8.2/10Very good (162 reviews)
11% off
£151
for 2 nights, 1 room
£75 per night
includes taxes & fees
Current River Inn
Reception
Front of property
Reception
Premium bedding, down duvets, pillow-top beds, in-room safe

The Farmstead Hotel

Caruthersville
8.8/10Excellent (445 reviews)
10% off
£148
for 2 nights, 1 room
£74 per night
includes taxes & fees
The Farmstead Hotel
Lobby sitting area
Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Meeting facility
Standard Room, 2 Queen Beds, Non Smoking | Free WiFi

Rockwood Inn

Cape Girardeau
10/10Exceptional (17 reviews)
10% off
£309
for 2 nights, 1 room
£154 per night
includes taxes & fees
Rockwood Inn
Exterior
Free daily full breakfast
Laptop workspace, iron/ironing board, free cots/infant beds
Exterior

Best Western Plus Sikeston

Sikeston
8.4/10Very good (1,003 reviews)
20% off
£149
for 2 nights, 1 room
£74 per night
includes taxes & fees
Best Western Plus Sikeston
Exterior
Property amenity
Lobby
Lobby

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson
8.8/10Excellent (650 reviews)
20% off
£130
for 2 nights, 1 room
£65 per night
includes taxes & fees
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Luxury Suite, 1 Queen Bed with Sofa bed, Kitchen | In-room dining
Fridge, microwave, coffee/tea maker
Desk, soundproofing, free WiFi, bed sheets
Exterior

Shepherd Mountain Inn

Ironton
9.4/10Exceptional (303 reviews)
10% off
£204
for 2 nights, 1 room
£102 per night
includes taxes & fees
Shepherd Mountain Inn
Front of property
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/bathtub, free toiletries, towels, soap
Combined shower/bathtub, free toiletries, towels, soap

New Orleans Inn Portageville

Portageville
8.0/10Very good (721 reviews)
10% off
£108
for 2 nights, 1 room
£54 per night
includes taxes & fees
New Orleans Inn Portageville

Check out pet-friendly hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Sikeston
£84
includes taxes & fees
20 Nov - 21 Nov
Drury Inn & Suites Sikeston, MO

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau
£77
includes taxes & fees
1 Dec - 2 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

Pear Tree Inn Cape Girardeau West

Cape Girardeau
£60
includes taxes & fees
20 Nov - 21 Nov
Pear Tree Inn Cape Girardeau West

Holiday Inn Poplar Bluff by IHG

Poplar Bluff
£87
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Poplar Bluff by IHG

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston
£51
includes taxes & fees
16 Nov - 17 Nov
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Sikeston

Sikeston
£82
includes taxes & fees
21 Nov - 22 Nov
Hampton Inn Sikeston

Hampton Inn Poplar Bluff

Poplar Bluff
£80
includes taxes & fees
23 Nov - 24 Nov
Hampton Inn Poplar Bluff

Echo Bluff State Park

Eminence
£119
includes taxes & fees
16 Nov - 17 Nov
Echo Bluff State Park

Drury Inn & Suites Poplar Bluff

Poplar Bluff
£81
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Poplar Bluff

Bullwinkles Rustic Lodge

Poplar Bluff
Bullwinkles Rustic Lodge
View all properties

You may also like hotels with hot tubs in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau
£77
includes taxes & fees
1 Dec - 2 Dec
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Jackson MO

Jackson
£71
includes taxes & fees
16 Nov - 17 Nov
Drury Inn & Suites Jackson MO

Drury Inn & Suites Poplar Bluff

Poplar Bluff
£81
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Poplar Bluff

Crown Pointe Lodge, BW Signature Collection

Farmington
£86
includes taxes & fees
23 Nov - 24 Nov
Crown Pointe Lodge, BW Signature Collection

New Orleans Inn Portageville

Portageville
New Orleans Inn Portageville

Drury Inn & Suites Cape Girardeau

Cape Girardeau
£77
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Cape Girardeau

Pear Tree Inn Sikeston

Sikeston
£67
includes taxes & fees
30 Nov - 1 Dec
Pear Tree Inn Sikeston

Hampton Inn Farmington

Farmington
£96
includes taxes & fees
23 Nov - 24 Nov
Hampton Inn Farmington

Quality Inn Perryville I-55

Perryville
£60
includes taxes & fees
26 Nov - 27 Nov
Quality Inn Perryville I-55

Drury Inn & Suites Hayti Caruthersville

Hayti
£81
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Hayti Caruthersville
View all properties

You can also stay at hotels with a pool in Southeast Missouri

Best Western Plus Sikeston

Sikeston
£73
includes taxes & fees
23 Nov - 24 Nov
Best Western Plus Sikeston

Current River Inn

Van Buren
£75
includes taxes & fees
16 Nov - 17 Nov
Current River Inn

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson
£69
includes taxes & fees
16 Nov - 17 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Pear Tree Inn Sikeston

Sikeston
£67
includes taxes & fees
30 Nov - 1 Dec
Pear Tree Inn Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston
£87
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express & Suites Sikeston Southwest by IHG

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington
£46
includes taxes & fees
30 Nov - 1 Dec
Baymont Inn and Suites by Wyndham Farmington, MO

Quality Inn

Cape Girardeau
£54
includes taxes & fees
14 Dec - 15 Dec
Quality Inn

Super 8 by Wyndham Perryville

Perryville
£58
includes taxes & fees
25 Nov - 26 Nov
Super 8 by Wyndham Perryville

Drury Inn & Suites Sikeston, MO

Sikeston
£84
includes taxes & fees
20 Nov - 21 Nov
Drury Inn & Suites Sikeston, MO

Hampton Inn Sikeston

Sikeston
£82
includes taxes & fees
21 Nov - 22 Nov
Hampton Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Central United States

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
See properties
A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay?
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Sunrise from the duck blind.
Photo by JG Morris

Lake Wappapello

4.3/5 (40 reviews)
Lake Wappapello is 1.8 mi (2.9 km) from central Wappapello, why not stop by during your stay?
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Century Casino Caruthersville

3.2/5 (31 reviews)
Century Casino Caruthersville is 1 mi (1.6 km) from central Caruthersville, why not stop by during your stay?
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Isle Casino Cape Girardeau

4.2/5 (104 reviews)
Isle Casino Cape Girardeau is 0.4 mi (0.7 km) from central Cape Girardeau, why not stop by during your stay?
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Learn more about Southeast Missouri

Southeast Missouri, well known for its wineries and riverfront, features attractions such as Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants and sights like Lake Wappapello State Park and Clearwater Lake.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard

Check out reviews of Southeast Missouri hotels guests love

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent
"Everything was very good; checkin was simple and fast."
Clinton 1-night trip
Posted 5 days ago
Fairfield Inn & Suites by Marriott Poplar Bluff
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

10/10 Excellent
"Amaiah at the front desk was amazing! She Answered all my questions and double checked that our room was ready since I was a15 minutes early."
lydia 1-night trip
Posted 6 days ago
Tru By Hilton Cape Girardeau
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Yes"
Gregory J 1-night trip
Posted 6 days ago
Baymont Inn and Suites by Wyndham Farmington, MO
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent
"The Room was very clean, We stayed on the 5th floor in a single king and the room had beautiful wood on the wall and boxed curtains. I really liked the layout. The staff was helpful, but we didn't need anything. I will stay there again for sure. I am not sure of the history of this building, but it was beautiful. It looked like old office building or something and the halls still looked like that. They had excellent midcentury styling. Even a letter shoot in the hall way, you can't use that though. The lobby was beautiful and if you need a cup of coffee there are two shops within throwing distance and I believe the lobby has Starbucks coffee in it. "
Ronald 1-night trip
Posted 6 days ago
Courtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"The room was very clean. The front desk staff were courteous and helpful. "
Terri 1-night trip
Posted 6 days ago
Drury Inn & Suites Sikeston, MO
The Riverview

The Riverview

10/10 Excellent
"Quiet clean room"
Meggan 1-night trip
Posted 6 days ago
The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Clean room and amenities were great"
Crystal 2-night trip
Posted 6 days ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Clean and friendly staff!!!"
Edward 1-night trip
Posted 6 days ago
Drury Inn & Suites Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

10/10 Excellent
"Nice place for a stay at a reasonable price."
Arthur 1-night trip
Posted 6 days ago
Pear Tree Inn Cape Girardeau Near the Medical Center

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