Hotels in Panacea

Sun, Feb 22
Tue, Feb 24
February 2026
21
March 2026

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Feb 21 - Feb 22
Tomorrow
Feb 22 - Feb 23
Next weekend
Feb 27 - Mar 1
In two weeks
Mar 6 - Mar 8

Where to stay in Panacea?

The Panacea Motel
The Panacea Motel
Panacea
  • Coastal retreat with on-site hiking trails, kayaking, and bay views in Panacea.
$105 nightly
$117 total
Mar 3 - Mar 4
Total with taxes and fees
The Panacea Motel
The Old Carrabelle Hotel
The Old Carrabelle Hotel
Carrabelle
$73 nightly
$81 total
Feb 24 - Feb 25
Total with taxes and fees
The Old Carrabelle Hotel
The Lodge at Wakulla Springs
The Lodge at Wakulla Springs
Crawfordville
  • Riverside escape with daily nature tours and historic dining room in Crawfordville.
$104 nightly
$117 total
Feb 22 - Feb 23
Total with taxes and fees
The Lodge at Wakulla Springs
Franklin Inn
Franklin Inn
Carrabelle
  • Wake up to Gulf Coast charm at this convenient motel in Carrabelle, Florida.
$84 nightly
$93 total
Feb 25 - Feb 26
Total with taxes and fees
Franklin Inn
The Moorings Hotel and Marina
The Moorings Hotel and Marina
Carrabelle
  • Waterfront getaway with marina and pool access at this coastal Carrabelle retreat.
$138 nightly
$153 total
Feb 23 - Feb 24
Total with taxes and fees
The Moorings Hotel and Marina
Best Western Wakulla Inn & Suites
Best Western Wakulla Inn & Suites
Crawfordville
$123 nightly
$137 total
Mar 19 - Mar 20
Total with taxes and fees
Best Western Wakulla Inn & Suites
St James Bay Golf & Pickleball Resort
St James Bay Golf & Pickleball Resort
Carrabelle
  • Golfing getaway on the bay with massages and poolside refreshments at the 18-hole resort.
$159 nightly
$176 total
Feb 24 - Feb 25
Total with taxes and fees
St James Bay Golf & Pickleball Resort
Wildwood Inn
Wildwood Inn
Crawfordville
$128 nightly
$142 total
Mar 8 - Mar 9
Total with taxes and fees
Wildwood Inn
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The Panacea Motel

The Panacea Motel
Panacea
$44 off
$122 nightly
$273 total
Total with taxes and fees
The Panacea Motel

Waterfront Ochlockonee Bay Cottage w/ Views!

Waterfront Ochlockonee Bay Cottage w/ Views!
Panacea
We have 1 left at
$309 nightly
$683 total
Total with taxes and fees
Waterfront Ochlockonee Bay Cottage w/ Views!

Nature Lover's Paradise: Hike, Bike & Fish!

Nature Lover's Paradise: Hike, Bike & Fish!
Panacea
We have 1 left at
$376 nightly
$825 total
Total with taxes and fees
Nature Lover's Paradise: Hike, Bike & Fish!

Florida Abode - Private Beach Access & Ocean Views

Florida Abode - Private Beach Access & Ocean Views
Panacea
We have 1 left at
$443 nightly
$974 total
Total with taxes and fees
Florida Abode - Private Beach Access & Ocean Views

Breezy Home w/ Grills, Pool & Beach Access!

Breezy Home w/ Grills, Pool & Beach Access!
Panacea
We have 1 left at
$395 nightly
$867 total
Total with taxes and fees
Breezy Home w/ Grills, Pool & Beach Access!

Alligator Point Beachfront Home w/ Private Hot Tub

Alligator Point Beachfront Home w/ Private Hot Tub
Panacea
We have 1 left at
$590 nightly
$1,299 total
Total with taxes and fees
Alligator Point Beachfront Home w/ Private Hot Tub
Our prices for hotels in Panacea are cheapest in February
Price trends for hotels in Panacea
Pricing is based on two traveler single night rates
View properties in February
Typical weather for Panacea
February
High 66°F / low 50°F. Sunny most days.
View properties in February
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Monthly weather averages (˚F)

Top landmarks in Panacea

Alligator Point Beach

3.5/5 (2 reviews)
Escape to Alligator Point's pristine shores where white sand meets clear, shallow waters perfect for wildlife spotting. Pack all essentials—this secluded slice of old Florida offers natural beauty without amenities.
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Mashes Sand Beach

Escape to Mashes Sands Beach's shallow, tea-colored waters where sandbars create a peaceful playground. Bring water shoes for rocky spots while beachcombing for hermit crabs and soaking in Gulf sunsets.
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Bald Point State Park

4.6/5 (9 reviews)
Where Ochlockonee Bay meets Apalachee Bay, you'll find pristine beaches and diverse ecosystems perfect for wildlife spotting. Visit in fall to witness the spectacular migration of raptors and monarch butterflies.
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Wilson Beach

Wilson Beach offers a serene Gulf Coast escape where soft sands meet gentle waves without the tourist crowds. Pack everything you need—there are no facilities, just pure unspoiled shoreline to enjoy.
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Panacea Springs

These historic mineral springs once drew crowds seeking healing waters in early 1900s Florida. Today you can explore the remaining structures while spotting at least seven small springs in the marshy setting.
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Public Beach Access

Shallow, crystal-clear waters make Mashes Sands Beach perfect for families with young children. Pack a picnic basket and arrive early to snag one of the limited parking spots at this peaceful local hideaway.
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Panacea Park

Panacea Park is worth a visit when in central Panacea.
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USS Mohawk CGC Veterans Memorial Reef

You might want to get your camera out and head to USS Mohawk CGC Veterans Memorial Reef— just one of the landmarks located 3.7 mi (6 km) from central Panacea.
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Learn more about Panacea

Notable for its natural beauty, Panacea features attractions such as Mashes Sand Beach and Alligator Point Beach. This beachside city has something for everyone including seafood restaurants as well as sights like Bald Point State Park and Wilson Beach. All are within a secluded setting.

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Sunset over a lake at Panacea, northern Florida, USA | NONE |

Check out reviews of Panacea hotels guests love

The Panacea Motel

The Panacea Motel

10/10 Excellent
"Room was clean and cozy. Very cute place to stay"
Elizabeth 1-night trip
Posted 3 days ago
The Panacea Motel

Frequently asked questions

How much does a hotel room cost in Panacea?
You can find top hotels in Panacea from $81 with options to suit your budget and needs. If you're looking for an affordable hotel in Panacea that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.
How can I find deals and earn rewards at Panacea hotels?
Discover great deals on Panacea hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Panacea hotels.
Can I book Panacea hotels with free cancellation?
To book a refundable Panacea hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What hotels do travelers like in Panacea?
The Panacea Motel is an accommodation that is popular with guests.
Can I book a refundable accommodation in Panacea?
If you're looking for the flexibility to change your travel plans to Panacea, most accommodations offer refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Panacea if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, browse our selection of 160 vacation homes. In addition, there are 18 apartments and 14 condos.
What will the weather in Panacea be like during my visit?
July and August are typically the warmest months in Panacea when the average temp is 81°F. January and February are the coldest months when the average temperature is 58°F. August and July are the months with the most rain.
Why should I book my Panacea hotel through Hotels.com?
There are lots of reasons to book your Panacea trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Panacea

Embrace Coastal Serenity: Discover the Enchantment of Panacea

Nestled along Florida's picturesque Gulf Coast, Panacea is a hidden gem for nature enthusiasts and beach lovers alike. This charming coastal town offers pristine sandy shores perfect for sunbathing and swimming, while nearby Wakulla Springs State Park beckons with lush landscapes and vibrant wildlife. Kayak through tranquil waters, explore scenic trails, and savor fresh seafood at local eateries. Whether you're seeking a romantic escape or an adventurous getaway, Panacea's serene atmosphere and stunning sunsets create an unforgettable backdrop for relaxation and exploration. Discover the unique allure of this off-the-beaten-path destination and reconnect with nature in its purest form.

Discover great hotels in Panacea

Panacea, Florida offers a range of hotel accommodations, from cozy motels to upscale options. Visitors can enjoy friendly service and comfortable rooms, making it a great spot for relaxation. Whether you're looking for a peaceful getaway or a home base for exploring the area, you'll find a variety of choices to suit your needs. Here are some of the best hotels in Panacea that our travelers love:

  1. Best Western Wakulla Inn & SuitesOpens in a new window: This inviting 2.5-star hotel caters to adventure seekers looking for a dynamic vacation experience. It features a range of adventure sports and recreation activities both onsite and nearby, including snorkeling, sailing, kayaking, and hiking. With multiple meeting rooms and a 24-hour business center, it provides essential amenities for those blending work with play. Travelers appreciate the lively atmosphere and the property’s close proximity to various adventurous pursuits, making it an ideal choice for those seeking an active getaway.
  2. Magnuson Hotel Wildwood InnOpens in a new window: As a 3.0-star hotel, Magnuson Hotel Wildwood Inn stands out as a pet-friendly option perfect for adventure lovers. The property allows pets and features a variety of adventure sports activities such as fishing, kayaking, and boat tours in nearby locations. With accessible business amenities, it provides a seamless experience for travelers looking for both leisure and work. Guests enjoy the welcoming vibe and the balance of adventure and comfort, making it a great choice for those wanting a unique and enjoyable stay.
  3. St James Bay Golf & Pickleball ResortOpens in a new window: This upscale 3.5-star hotel is a haven for golf enthusiasts. St James Bay Golf & Pickleball Resort offers a premier golfing experience along with a plethora of adventure sports options like hunting, kayaking, and waterskiing nearby. The property’s lush surroundings and carefully curated recreational activities create an inviting atmosphere for travelers seeking a distinctive adventure-themed getaway. Visitors revel in the sophisticated ambiance and the variety of outdoor experiences available, solidifying its status as a top choice for those wanting to indulge in both relaxation and excitement.

Top locations to stay in Panacea

Some of the best areas to stay in Panacea, Florida, are Saint Teresa, Alligator Point, and Crawfordville. Saint Teresa offers serene beaches ideal for relaxation, Alligator Point is perfect for nature lovers with its scenic coastal views, and Crawfordville boasts charming local attractions. For first-time visitors, Saint Teresa is the best choice for a beach getaway.

  1. Saint TeresaOpens in a new window: Nestled along the Gulf Coast, Saint Teresa is a serene seaside getaway known for its stunning natural beauty and peaceful atmosphere. Visitors can enjoy the pristine beaches, perfect for sunbathing or leisurely walks by the water. The area is also great for nature enthusiasts, with opportunities for birdwatching and exploring local wildlife. Saint Teresa's quaint surroundings provide a relaxing retreat, making it an ideal choice for travelers seeking tranquility and scenic views.
  2. Alligator PointOpens in a new window: Just a short drive from Saint Teresa, Alligator Point offers a unique coastal experience with its picturesque beaches and abundant outdoor activities. This charming community is perfect for fishing, kayaking, and enjoying the breathtaking sunsets. With its laid-back vibe, Alligator Point attracts those looking to connect with nature while providing a cozy environment for relaxation. The nearby estuaries and tidal areas are perfect for exploring marine life, making it a delightful spot for adventurers.
  3. CrawfordvilleOpens in a new window: A bit inland, Crawfordville serves as a gateway to discover the natural wonders of the Big Bend region. This friendly town boasts beautiful parks, hiking trails, and opportunities for birdwatching, ideal for those who appreciate the great outdoors. While it may not have the coastal charm of its neighbors, Crawfordville offers a slice of local life with its small-town feel and access to the nearby Wakulla Springs State Park, where visitors can enjoy swimming and wildlife tours. It's a perfect base for exploring the surrounding areas.

Things to do in Panacea

Panacea beckons with its stunning beaches, lush forests, and serene lakes, inviting travelers to bask in nature's beauty. Enjoy thrilling activities like dolphin watching, fishing, and hiking through scenic trails. As the sun sets, unwind with breathtaking views, making this destination a must-visit for outdoor enthusiasts.

  • Wakulla Springs State ParkOpens in a new window – Dive into the natural beauty of Wakulla Springs State Park, where you can explore lush landscapes and enjoy activities like swimming, hiking, and wildlife spotting. The crystal-clear waters are perfect for a refreshing swim or a scenic boat tour to see manatees and various bird species.
  • Shell Point BeachOpens in a new window – Relax at Shell Point Beach, a serene spot ideal for sunbathing, swimming, and beachcombing. The gentle waves and soft sands create a relaxing atmosphere, perfect for families and solo travelers alike. Don’t forget to bring your shells back as souvenirs!
  • St. Marks National Wildlife RefugeOpens in a new window – Discover the stunning biodiversity at St. Marks National Wildlife Refuge. Wander through trails that lead you past wetlands and coastal habitats, where you can spot migratory birds and other wildlife. It's an excellent place for photography and nature walks.
  • St. Marks LighthouseOpens in a new window – Visit the historic St. Marks Lighthouse, a picturesque landmark that offers a glimpse into the area’s maritime history. Climb nearby trails for splendid views of the surrounding waters and wetlands, making it a great spot for both photography and relaxation.
  • Alligator Point BeachOpens in a new window – Head to Alligator Point Beach for a more secluded beach experience. Enjoy the tranquility of this less-crowded spot, where you can stroll along the shore, collect seashells, or simply soak up the sun in a peaceful environment.

5 tips for savvy savings when booking a hotel in Panacea

  1. Book for the cheapest times: The most affordable time to visit Panacea is during January, July, and December, when hotel prices are typically lower. For those looking to explore the area’s historical and cultural landmarks, a stay of at least 2 to 3 days is recommended. This budget-friendly duration allows visitors to enjoy the beautiful beaches, observe dolphins, savor fresh seafood, and experience the area's secluded natural attractions. With opportunities for fishing, hunting, and witnessing stunning sunsets, Panacea offers great value for money, making it an ideal destination for travelers on a budget.
  2. Look for last-minute deals on Hotels.com: To uncover last-minute deals for hotels in Panacea, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window sections on Hotels.com, where you may discover discounted rates as your travel date approaches. Consider enabling email alerts or push notifications to stay updated on flash sales and special promotions, increasing your chances of snagging a great offer. Additionally, the Smart ShoppingOpens in a new window feature in the app allows you to compare hotel prices and amenities, ensuring you're more likely to see the best options available. With these tips, you can stay informed about price drops and availability for your ideal getaway.
  3. Be flexible with dates: Prices can fluctuate depending on factors like the hotel's location, star rating, and the time of year, so being flexible with your travel dates might help you save on your stay at the Panacea hotel. If you're seeking unique accommodations, boutique hotels often provide a more personalized experience and may offer better value. When you book through Hotels.com, we’ll inform you whether the price for your chosen dates is above or below the average. If the price is on the higher side, we’ll recommend more affordable dates, which could help you secure a better deal.
  4. Consider your location: Staying near major attractions or city centers can be convenient, but it usually tends to come with higher prices. For more affordable options, consider hotels in neighborhoods that are a bit further out, striking a balance between cost and accessibility to the sites you want to visit. You might also look into independent hotels located further away, which can offer a more authentic and budget-friendly experience.
  5. Become a Member: Join our membership program for free and start planning your next getaway in Panacea! Enjoy exclusive access to over 100,000 hotels worldwide at special member rates. As you progress through the membership tiers, you'll unlock fantastic perks, including complimentary room upgrades (when available) and discounts on food and beverages at select VIP Access properties. Don't miss out on these great benefits—become a member today and enhance your travel experience!

Best time to go to Panacea

Panacea experiences its lowest average temperature in January, at 53.6°F (12.0°C), while July to August are the hottest months, with an average temperature of 81.7°F (27.6°C). August is usually the wettest month. April, June, and July are the peak travel months in Panacea, attracting a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light to moderate rainfall. On the other hand, October to December tend to be quieter times to visit, marked by light rainfall and mostly sunny conditions.

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